logo

Copyright ©2024 REDLARA

Trabalhos

REDLARA: THE RISK OF MAJOR BIRTH DEFECTS AFTER INTRACYTOPLASMIC SPERM INJECTION AND IN VITRO ERTILIZATION

MICHÈLE HANSEN,M.P.H.,JENNIFER J.KURINCZUK,M.D.,CAROL BOWER,M.B.,B.S.,PH.D.,AND SANDRA WEBB,PH.D.

N Engl J Med 2002;346:725-30.

Preparado por:
Dra. Claudia Borrero 

ABSTRACT 
Background It is not known whether infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have a higher risk of birth defects than infants conceived naturally.

Methods We obtained data from three registries in Western Australia on births,births after assisted conception,and major birth defects in infants born between 1993 and 1997.We assessed the prevalence of major birth defects diagnosed by one year of age in infants conceived naturally or with use oftoplasmic sperm injection or in vitro fertilization.

Results Twenty-six of the 301 infants conceived intracytoplasmic sperm injection (8.6 percent) and 75 of the 837 infants conceived with in vitro fertilization (9 0 percent)had a major birth defect diagnosed by one year of age,as compared with 168 of the 4000 naturally conceived infants (4.2 percent; P<0 001 for the comparison between either type of technology and natural conception).As compared natural conception,the odds ratio for a major birth defect by one year of age,after adjustment for maternal age and parity,the sex of the infant,and correlation between siblings,was 2.0 (95 percent confidence interval,1.3 to 3.2)with intracytoplasmic sperm injection,and 2.0 (95 percent confidence in terval,1.5 to 2.9)with in vitro fertilization.Infants conceived with use of assisted reproductive technology were more likely than naturally conceived infants to have multiple major defects and to have mal and musculoskeletal defects.

Conclusions Infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have twice as high a risk of a major birth defect as naturallyconceived infants.

Tem alguma dúvida?

Estamos a sua disposição.

AC2F
EDUCAÇÃO REDLARA PEC ONLINE

Glossário revisado da Terminologia das Técnicas de Reprodução Assistida (TRA), 2009. Comintê Internacional para Monitorização da Tecnologia Reprodutoiva Assistida (ICMART) e Organização Mundial de Saúde (OMS)