Information is presented on 34,102 cycles of assisted reproduction performed during the year 2007, by 138 centers in 11 countries; together with information on deliveries and babies born up to September, 2008.
A total of 25,736 IVF/ICSI cycles performed resulted in 7,247 clinical pregnancies. Pregnancy rates were higher in women ≤34 years, with male factor as a cause of infertility, with the use of GnRH agonists, and transfer of more embryos – even though the transfer of ≥3 embryos showed no clinically significant change -, and the transfer of embryos at blastocyst stage. Improved clinical pregnancy rates were not associated with the route of administration during the luteal phase, mode of fertilization nor the use of Assisted Hatching. 76% of clinical pregnancies were single. A higher frequency of multiple gestation – especially extreme – was associated to women ≤34 years and the transfer of ≥3 embryos. Delivery rate of ≥ 1 live birth, by transfer, was 26%.
A total of 2,700 elective one and two embryo transfers were reported, representing 13% of embryo transfers. This frequency was greater in women ≤34 years. All age categories showed improved pregnancy rates with elective transfer of 2 embryos. Rate of multiple gestation was similar when ≥3 embryos were transferred, although the rate of extreme multiple gestation was considerably lower.
A total of 3,397 thawed embryo transfers were reported, mostly in women ≤34 years. The delivery rate with ≥1 live births, per transfer, was 17%.
Furthermore, 4,697 transfers with embryos product of oocyte donation were reported, majority in women ≥40 years. Donor cycles represented 64% of aspirations. Pregnancy rater varied slightly with respect to the age of the recipient and the frequency of multiple gestation. The frequency of multiple gestation, particularly extreme, was higher when more embryos were transferred, specially with ≥3. The delivery rate with ≥1 live births in fresh cycles was 31%.
A total of 10,168 clinical pregnancies were reported, 18% of which aborted spontaneously. This frequency was higher in cycles with thawed embryo transfers, autologous or product of oocyte donation. Of 7,928 deliveries reported, 76% were single. Increased frequency of prematuriry was associated with higher order deliveries. Of the 10,041 babies reported, 60% were single. Babies or higher gestational order showed greater risk of low birth weight and perinatal mortality.
This report includes, for the first time, information on IUI cycles; 7,006 cycles using husband´s semen, and 1,270 using donor semen. 56% of cycles were reported in women ≤34 years. Improved pregnancy rates were associated with: the use of donor semen, woman´s age (≤34 years) and ovulation induction using CC+rFSH. 88% of all babies born thanks to these techniques were single.
Regional trends highlight the continued increase in the woman´s age – 56% of IVF/ICSI embryo transfers were in women ≥ 35 years – and to the use of ICSI, which represents 83% of aspirations. The mean number of embryos transferred in IVF/ICSI cycles shows a gradual decrease to 2.6 in the year 2007, even though 54% of transfers were of ≥3 embryos. This lowered the frequency of extreme multiple gestation to 6.9%.
Click here in order to download complete document in PDF , or click below on the topic of interest :
- Cover page – editors – Board of Directors (pag. 1 a 4)
- Acknowledgements & Participating centers (pag. 5 a 9)
- Contents (pag. 10 a 14)
- Summary (pag. 15)
- Introduction (pag. 16 a 17)
- ART Procedures (pag. 18)
- Chapter 1: Description of ART procedures (pag. 19 a 21)
- Chapter 2: IVF & ICSI (pag. 24 a 35)
- Elective Embryo Transfer (pag. 36-38)
- GIFT/TOMI (pag. 39-40)
- Preimplantation Genetic Diagnosis (pag. 41-42)
- Chapter 3: Thawed embryo transfers (pag. 43 a 48)
- Chapter 4: Oocyte Donation (pag. 49 a 54)
- Chapter 5: Pregnacies, Deliveries & Babies (pag. 55 a 63)
- Chapter 6: Intrauterine Inseminations (pag. 64 a 69)
- Chapter 7: Regional Trends (2000-2007) (pag. 70 a 75)