"We invite all centres of REDLARA and new centres performing Assisted Reproduction procedures to report their data corresponding to the year 2016.
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In this publication, the results of Assisted Reproduction performed in 13 countries of Latin America, in 1997, in 78 affiliated centres of the RED were reported. There were 11.530 therapeutic cycles started and 9.900 transferences that include, among others, 3.906 IVF, 177 GIFT, 3.789 ICSI, 560 OD and 599 cycles with thawed embryos. From these procedures, the majority was performed in Brazil (45%) and Argentine (21.2%). 39.5% of the transferred cycles are related to IVF procedures and 38.3% to ICSI. 49 of the 78 centres performed ICSI procedures.
The clinical pregnancy rate (TEC) by aspiration and births with liveborn were 23.1% and 17.9% for IVF, 28.1% and 23.3% for ICSI. From the 9.900 transferences performed, 3.105 live children were born (1.488 unique, 1.072 twins, 473 triplets and 72 quadruplets or more). This reflects the multiple gestation rates that were 29.3% for IVF and 27.7% for ICSI. On the other hand, the TEC by cryopreserved embryos transferred (559 transferences) was 19.1%, originating 69 births with at least one liveborn. From the 526 transferences with embryos pertaining to OD cycles, the TEC by transference was 36.7%, originating 157 births with at least one liveborn.
For the ovarian stimulation, the combination GnRh + gonadotrophins was used in 80.9% of the cases, being TEC significantly higher than in the cycles in which only clomifene or gonadotrophins were used (24.6% versus 17.3% and 19.6%, respectively).
The TEC decreases when the age of the patient increases in all procedures. To the interior of each category of age, the TEC does not differ according to the diagnostic category.
The implantation rates are significantly higher in women aged under 35 in relation to those aged 35 – 39 when to transfer 1 to 4 embryos. Comparing women aged 35 – 39 with women aged = 40, the differences are significant only to transfer 5 embryos.
The chance of gestation in IVF increases significantly until the transference of 3 embryos, and there is not difference to transfer 4, however, the same does not occur in ICSI, where the transference of 4 embryos increases significantly the chance of gestation in relation to 3 embryos. The stabilization occurs to transfer 5. On the other hand, as in IVF as in ICSI, in women aged < 35, the multiple gestation rate (MG) is significantly superior to transfer 3 embryos in relation to 2. The extreme multiple gestation rate (MG) does no differ significantly in women aged < 35 in relation to women aged 35 – 39, independently to the number of embryos transferred. The number of stillbirth (10.4%) and perinatal death (10.4%) increase significantly in the gestations of quadruplets in relation to triplets and twins.