"We invite all centres of REDLARA and new centres performing Assisted Reproduction procedures to report their data corresponding to the year 2016.
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In this publication were reported the results of the Assisted Reproduction procedures performed in 1996, in which a total of 10.359 cycles started and 2.503 liveborn (1.278 unique, 821 twins, 331 triplets and 73 quadruplets or more) were included. The medium age of the treated women was 33. The three countries that contributed with the higher number of cases were Brazil (38.7%), Argentine (26.1%) and Mexico (9.9%). From the total of the cycles started, 51.8% are related to IVF, 44.1% to ICSI and 4.2% to GIFT. This distribution points a substantial change in the application of new reproductive technologies, as in 1993 ICSI represented only 0.2%, 6.1% in 1994 and 32.7% in 1995. Between 1993 and 1995, the number of centers in which reported ICSI procedures was 2, 10 and 27. In the present time, 41 centres belonging to 10 countries reported procedures of micromanipulation, as ICSI, Assisted Hatching and the combination of both. The clinical pregnancy rates (TEC) and birth with one liveborn, by aspiration, were 21.2% and 16.1% for IVF, 24.6% for ICSI and 36.4% and 28.9% for GIFT.
In IVF, due to tubal factors, the TEC and the chance of pregnancy (RD) are significantly lower as the age of the woman increases. The chance of pregnancy is 1.4 times higher in women aged 30 – 34 in relation to those aged 35 – 39. At the same time, this age range has a chance of 1.7 times higher to those women aged =40. In the male factors, to the interior of each age category, the transference of 1 or 2 embryos has a positive global effect in the TEC and RD.
This relation loses statistical meaning with the transference of 4 embryos or more. The implantation rate (number of gestational sacs / number of embryos transferred) is significantly higher in women aged < 35 in relation to those aged 35 – 39. At the same time, the implantation rate in this group of age is also significantly higher than in the women aged =40.
The multiple pregnancy rates were analyzed by the first time, considering the number of embryos transferred and the age of the woman. In women aged < 35, the multiple pregnancy rate to transfer 3, 4 and 5 embryos is 23.5%, 33.2% and 43.3% respectively. Moreover, the extreme multiple gestation (= 3 sacs) is 4.9%, 16.4% and 21.2% respectively. In relation to the transference of cryopreserved embryos, the global TEC is 18.2% and vary between 8% to transfer 2 embryos to 33.3% to transfer 5. The implantation rates are lower to transfer thawed embryos in relation to the fresh ones; however, the spontaneous miscarriage rates are 20% for fresh embryos and 15.3% for thawed embryos.
In ICSI, the number of embryos transferred in women aged < 35 affects the TEC and the implantation rate in a similar way than in IVF. In women aged 35 – 39 or = 40, the number of embryos transferred does not affect significantly the TEC. In a total of 3.282 transferences and 906 clinical gestations, the miscarriage rate is 17% what does not differ significantly than IVF.
The TEC with donated oocytes (OD) is not affected by the age of the receptor, being 34.6% in women aged <35 and 40.3% in those aged =40. The clinical miscarriage rate is 14.6%. The age of the receptors (women aged =35) positively influences the pregnancy rates.
In ICSI, the number of embryos transferred in women aged <35 affects the TEC and the implantation rate similarly than in IVF. In women aged 35 – 39 or =40, the number of embryos transferred does not affect significantly the TEC. In a total of 3.282 transferences and 906 clinical gestations, the abortion rate is 17%, what does not differ significantly in IVF.